Adenosine medication for insomnia9/1/2023 Reference: Korkutata, M., Saitoh, T., Cherasse, Y., Ioka, S., Duo, F., Qin, R., … Lazarus, M. For further information, please contact the cited source. Note: material may have been edited for length and content. This article has been republished from materials provided by the University of Tsukuba. Tsuyoshi Saitoh, another lead author of the paper. Therefore, "many obstacles remain to be overcome in generating a novel drug for the treatment of insomnia in humans, but we believe that our discovery will unlock the development of the next-generation sleeping pill." explained medicinal chemist Dr. "We believe that allosteric modulators of A2A receptors may help people with sleep problems to fall asleep" says Mustafa Korkutata, the first author of the paper.Īlthough mice are the most commonly used model organism of human disease, results in mice, however, are often not always reliable for predicting human study outcomes. A positive allosteric modulator may evoke selective physiologic A2A receptor responses because, in contrast to an A2A receptor agonist, its actions are limited to when and where adenosine is released. Researchers at the International Institute for Integrative Sleep Medicine (WPI-IIIS) at the University of Tsukuba succeeded in identifying the first positive allosteric modulator for adenosine A2A receptors and demonstrated that enhancing A2A receptor signaling induces sleep that is indistinguishable from the major component of natural sleep, known as slow-wave sleep, as it is characterized by slow and high-voltage brain waves, without affecting cardiovascular function. Although adenosine A2A receptor agonists strongly induce sleep, their adverse cardiovascular effects preclude their use in treating sleep disorders. A new paper published on Octoin the journal Neuropharmacology finds that enhancing endogenous signaling of adenosine A2A receptors may be an alternative strategy for treating insomnia.Īdenosine has long been known to represent a state of relative energy deficiency and to induce sleep via adenosine receptors. These medications, however, are plagued by a wide range of adverse effects, including muscle relaxation, rebound insomnia, changes in appetite, next-day sedation, cognitive impairment, amnesic effects, and development of drug tolerance and dependence. The most widely prescribed agents for the treatment of insomnia are benzodiazepines and non-benzodiazepines, which are central nervous system depressants that enhance signaling of the inhibitory neurotransmitter γ-aminobutyric acid. Moreover, insomnia frequently co-occurs with a wide range of psychiatric disorders, including depression and anorexia. Insomnia is one of the major sleep problems with an estimated prevalence of 10% to 15% in the general population and 30% to 60% in the older population.
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